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PLS is a rare autosomal recessive disease in which DPP1 insufficiency, which is caused by a mutation in the DPP1 gene ( CTSC ), results in diffuse palmoplantar hyperkeratosis, severe prepubertal periodontitis, and premature loss of both deciduous and permanent teeth ( Characterization of NSPs from patients with PLS revealed a DPP1-independent processing and maturating pathway for NSPs that is catalyzed by at least one DPP1-like protease ( In the human promyelocytic HL-60 precursor cell line, CatS/CatL inhibition nearly abolishes proDPP1 maturation, although it does not result in significant NSP inactivation

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Retrospective analysis of OA progress in type 2 diabetes patients showed the lower ratio of knee arthroplasty in patients treated with metformin, suggesting the possibility of clinical effectiveness

Finally, we used random forest analysis to assess the contribution of the nine key factors to IMF content variation (Fig